一个与机器学习算法集成的临床预测模型揭示了饮食中的欧米茄-3,其成分和衰老生物标志物之间的关联
Zhaoqi Yan1,2, Yifeng Xu2, Ting Peng3
1Department of Rehabilitation Medicine, The Third Hospital of Nanchang, Nanchang People's Hospital, Nanchang, China.
Journal of food science
|July 24, 2025
概括
饮食中摄入较高的欧米茄-3脂肪酸,特别是阿尔法-烯酸 (ALA),与老年人生物衰老的减缓有关. 这表明omega-3可能会促进长寿和更健康的衰老.
科学领域:
- 营养科学 营养科学
- 老年学是一门学科.
- 衰老的生物标志物
背景情况:
- 饮食中的欧米茄-3脂肪酸 (阿尔法-烯酸[ALA],乙酸[EPA],和多可萨赫萨酸[DHA]) 在细胞健康中起着至关重要的作用.
- 衰老与各种生物变化有关,包括DNA甲基化年龄,端粒长度和表型年龄.
研究的目的:
- 调查饮食中的欧米茄-3摄入量与老年人中关键衰老生物标志物之间的关联.
- 使用机器学习和门德尔随机化,构建和解释衰老的预测模型.
主要方法:
- 使用线性回归和受限制的立方斜线对NHANES数据 (1999-2002) 的横截面分析.
- 机器学习 (LSVM) 与SHAP用于模型解释性.
- 门德尔随机化 (MR) 推断因果关系.
主要成果:
- 高欧米茄-3和ALA摄入量与DNA甲基化年龄 (HorvathAge) 和表型年龄相反相关,与端粒长度 (Horvathtelo) 有正相关.
- MR分析验证了omega-3和ALA的抗衰老作用.
- 观察到非线性剂量反应效应,omega-3s和ALA改善衰老生物标志物.
结论:
- 饮食中的欧米茄-3脂肪酸,特别是ALA,与老年人生物衰老的减缓有显著的关联.
- 这些发现支持了富含omega-3的饮食促进健康衰老和长寿的潜力.
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