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内皮激活和压力指数用于预测喘死亡率
Yili He1, Yang Li1, Yuan Xiaojin1
1Department of Critical Care, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China.
Frontiers in medicine
|July 24, 2025
概括
更高的内皮激活和压力指数 (EASIX) 水平预测了进入ICU的喘患者的死亡风险增加. 这一发现强调了EASIX作为短期和中期结果的有价值的预后标记.
科学领域:
- 关键护理医学 关键护理医学
- 肺部病理学 肺部病理学
- 生物标志物 生物标志物
背景情况:
- 在各种疾病中建立了内皮激活和压力指数 (EASIX) 的预后意义.
- 它与重症监护室 (ICU) 喘患者的短期和中期结果的关联仍然不清楚.
研究的目的:
- 调查录入ICU的喘患者的 log2 ((EASIX) 和住院死亡率之间的关系.
- 评估 log2 ((EASIX) 对短期和中期死亡率的预后性能.
主要方法:
- 来自MIMIC-IV数据库的3737名喘患者的回顾性队列研究.
- 在ICU入院第一天使用血小板计数,肌素和乳酸脱酶计算的Log2 (((EASIX).
- 多变量考克斯回归和ROC分析用于评估死亡率关联和预测性能.
主要成果:
- 较高的log2 ((EASIX) 与增加的28天和60天住院死亡率 (HR=1.14和HR=1.13,分别) 独立相关.
- 在log2 ((EASIX)) 的最高三位数中,与最低三位数相比,死亡率明显更高.
- 对于28天 (AUC=0.892) 和60天 (AUC=0.881) 的死亡率,ROC分析显示出良好的预测性能.
结论:
- 升高的log2 (EASIX) 是喘患者医院死亡率增加的独立预测因素.
- 在这一群体中,EASIX对短期和中期死亡率的预后表现良好.
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