在患有Sjögren病的患者和匹配的对照人群中,通过外周动脉度测量的内皮微血管没有差异
Franziska Maria Tapken1, Nadine Zehrfeld1, Malin Abelmann1,2,3
1Department of Rheumatology and Immunology, Hannover Medical School, Hanover, Germany.
Frontiers in medicine
|July 24, 2025
概括
与使用外围动脉度计的对照组相比,Sjögren病患者的内皮功能没有改变. 在这项研究中,增加的体重指数,而不是Sjögren病,预测了内皮功能减少.
科学领域:
- 类风湿病学 类风湿病学
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
背景情况:
- 肖格伦氏病 (SjD) 是一种自身免疫性疾病,影响外分泌腺,导致干燥,疼痛和疲劳.
- SjD患者心血管风险增加,与亚临床动脉样硬化有关.
- 早期识别SjD对于管理发病率和死亡率至关重要.
研究的目的:
- 用反应性高血症指数 (RHI) 来评估Sjögren病患者的内皮功能.
- 确定RHI是否可以识别SjD的早期心血管风险.
- 为了比较SjD患者和健康对照者之间的RHI.
主要方法:
- 招募了49名符合ACR/EULAR 2016标准的SjD患者和27名健康对照.
- 通过使用EndoPAT®装置通过反应性高血压指数 (RHI) 测量内皮功能.
- 分析了RHI值,认为<1.67是病理的.
主要成果:
- 在SjD患者和健康对照人群之间没有观察到RHI的显著差异.
- 年龄和心血管风险因素在各组之间是可比的.
- 体重指数增加是低RHI的唯一显著预测因素 (p=0.036).
结论:
- EndoPAT测量可能不适合检测特定于Sjögren病的内皮功能障碍.
- 体重指数是影响内皮功能的一个重要因素.
- 需要进一步的研究来确定SjD中心血管风险的可靠生物标志物.
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