相关实验视频
Updated: Jul 27, 2026

14:33
Morphometric Analyses of Retinal Sections
Published on: February 19, 2012
10.4K
在中国老年人中,认知功能与视网膜结构和血管成像参数相关
Manqiao Wang1, Limei Chen1, Yi Gong1
1Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease Eye Institute and School of Optometry Tianjin Medical University Eye Hospital Tianjin China.
Alzheimer's & dementia (Amsterdam, Netherlands)
|July 24, 2025
概括
老年人的认知障碍与视网膜和胸膜较薄有关. 光学连贯断层扫描血管造影 (OCT/OCTA) 显示了早期认知障碍查的潜力.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 老年学是一门学科.
背景情况:
- 认知障碍 (CI) 在老年人群中是一个日益严重的公共卫生问题.
- 早期发现CI对于及时干预和管理至关重要.
- 目前正在积极寻找用于认知健康的非侵入性生物标志物.
研究的目的:
- 调查老年人认知状态和视网膜参数之间的关联.
- 探索光学连贯断层扫描血管学 (OCT/OCTA) 在评估认知健康方面的实用性.
主要方法:
- 一项以人口为基础的研究 (北京眼研究) 涉及来自中国天津的3606名老年人.
- 视网膜厚度和血管密度 (VD) 用OCT/OCTA.测量.
- 认知功能被评估使用迷你精神状态检查 (MMSE).
主要成果:
- 在32.7%的参与者中存在认知障碍.
- 与没有CI的个体相比,CI患者的平均视网膜厚度 (p=0.007) 和胆膜厚度 (p<0.001) 降低了.
- 在MMSE得分和视网膜参数 (r=0.518到0.530) 之间观察到正相关性.
结论:
- 视网膜和冠状腺稀疏与老年人认知障碍有显著的关联.
- OCT/OCTA可以作为一种非侵入性工具,用于早期查认知障碍.
- 血管风险因素的管理可以使视网膜和认知健康受益.
相关概念视频
Vision
Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
The Effect of Aging on Tissues
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Photoreceptors and Visual Pathways
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...

