在寒冷的天气中,表达Foxp2的神经元是维持核心体温所必需的
Fillan S Grady1,2, Shantelle A Graff1,2, McKenna M Warnock1,2
1Department of Neurology, University of Iowa, Iowa City, IA 52242, USA.
iScience
|July 24, 2025
概括
科学家们在大脑中发现了特定的神经元,这些神经元对于感知寒冷和保持体温至关重要. 这些在侧面抛臂核中的Foxp2表达神经元对于在寒冷环境中生存至关重要.
科学领域:
- 神经科学是一个神经科学.
- 环境生理学环境生理学
- 哺乳动物的温度调节
背景情况:
- 在寒冷的环境中维持核心体温需要复杂的适应性反应,称为冷防御.
- 控制这些寒冷防御机制的精确神经回路在很大程度上仍未确定.
- 了解这些循环对于理解寒冷气候中的生存策略至关重要.
研究的目的:
- 为了确定负责编排适应性反应对寒冷环境温度的神经电路.
- 为了研究侧侧核 (PB) 中特定神经元群体在温度调节中的作用.
- 阐明Foxp2-表达神经元在感知寒冷和生存中的功能.
主要方法:
- 使用了暴露在寒冷环境温度下的小鼠模型.
- 鉴定和表征了一组特定的Atoh1衍生的,在侧向甲核 (PB) 中表达Foxp2的谷氨基神经元.
- 采用基因操纵来消除表达Foxp2的PB神经元,并评估生理和行为反应.
主要成果:
- 暴露在寒冷中激活了PB中的Foxp2表达神经元的特定群体.
- 消除这些神经元导致体温在寒冷中显著下降.
- 缺乏这些神经元的小鼠表现出代谢受损,运动活动减少,在寒冷条件下热分辨能力不足,同时在室温下保持正常功能.
结论:
- 通过侧侧核中的Foxp2表达神经元处理的热传感信息对于感知寒冷至关重要.
- 这些特定的神经元对于启动在寒冷环境中生存所需的适当生理和行为反应至关重要.
- 这项研究确定了冷防御系统的关键神经元件.
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