习惯学习和决策回路易受2型糖尿病的血糖变化影响:一项纵向研究
Carolina Moreno1,2,3, Otília C d'Almeida1,3, Joana Crisóstomo1
1Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
2型糖尿病 (T2DM) 中的血糖变化 (GV) 与长期的大脑缩有关,特别是在对记忆和决策至关重要的区域. 较高的葡萄糖波动与增加的灰质体积损失相关,突出显示GV是T2DM相关的大脑变化的关键因素.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 放射学 放射学是一门学科.
背景情况:
- 2型糖尿病 (T2DM) 与灰色质量 (GM) 量的减少有关.
- 血糖控制,特别是血糖变化 (GV) 对T2DM中长期大脑缩的影响仍未得到充分研究,特别是在敏感的大脑区域.
研究的目的:
- 确定血糖变异性 (GV) 对T2DM患者大脑体积长期变化的影响.
- 在T2DM患者中确定受GV诱导缩影响的特定大脑区域.
主要方法:
- 一项纵向研究在基线和7年后评估了170名个人 (85名T2DM).
- 使用3T MRI和FreeSurfer 7纵向管道分析了大脑区域体积.
- 计算了血糖变化指标,包括血糖外流的平均幅度 (MAGE).
主要成果:
- 在T2DM患者的特定皮层和皮下区域中,在GV指标和灰质 (GM) 体积变化 (对称百分比变化-SPC) 之间观察到显著的负相关性.
- MAGE显示,叶,胰岛,丘脑,海马和门的缩与显著的相关性.
- 增加的MAGE与较高的叶缩率有关,每增加1 mmol/L的MAGE,SPC下降1.2%.
结论:
- 在T2DM中长度灰色质缩表现出与血糖变异相关的区域特异性模式.
- GV似乎调解T2DM对奖励预测错误电路的神经影响,影响参与习惯学习,决策和记忆的区域.
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