系统性炎症指数和营养标记在预测急性结石胆囊炎及其严重性的价值
Bing He1, Qiguang He2, Zhiyong Lai3
1Department of First Clinical Medical College, Shanxi Medical University, Taiyuan, Shanxi, People's Republic of China.
Journal of inflammation research
|July 24, 2025
概括
中性粒细胞与淋巴细胞的比率 (NLR) 有效地预测了急性结石胆囊炎 (ACC) 的严重程度. 炎症标志物升高和营养指数下降表明ACC风险较高,需要及时干预.
科学领域:
- 胃肠病学和肝病学
- 手术病理学手术病理学
- 临床免疫学临床免疫学
背景情况:
- 急性结石胆囊炎 (ACC) 是一个重大的临床挑战.
- 准确预测ACC严重程度对于及时有效的患者管理至关重要.
- 营养和炎症标记因其诊断潜力而越来越被认可.
研究的目的:
- 评估各种炎症和营养标志物对ACC严重性的预测准确度.
- 为了确定这些标记器在区分ACC阶段时的最佳切断值.
- 确定用于区分不同形式的急性胆囊炎的关键指标.
主要方法:
- 追溯队列研究包括130例ACC和109例慢性结石胆囊炎 (CCC) 病例.
- 对临床数据和炎症免疫标记物的分析:NLR,PLR,SII,MLR,SIRI,PNI.
- 确定每个标记物的最佳截止值和预测能力 (AUC).
主要成果:
- NLR>2.499是区分ACC和CCC的最强预测因素 (AUC=0.896).
- SII > 1098最好的预测是从急性性胆囊炎 (APC) 引起的急性简单胆囊炎 (ASC) (AUC=0.73).
- 在区分APC与急性性胆囊炎 (AGC) (AUC=0.826) 中,NLR>7.232显示出最高的准确性.
结论:
- 系统性炎症指数和营养标志物对于预测ACC及其严重程度非常有价值.
- 炎症标志物升高和营养状况下降与ACC严重性增加相关.
- 这些标志物可以指导针对严重胆囊炎的及时和适当的临床干预.
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