在外围神经受伤后和神经再生期间,施万细胞通过类似EMT的程序进行重编程
Wenyu Dai1, Yang Miao2, Sheng Yi1
1Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China.
Frontiers in cell and developmental biology
|July 24, 2025
概括
表皮-介质细胞过渡 (EMT) 驱动细胞在发育和疾病中的可塑性. 在神经损伤中准类似EMT的施万细胞可以改善再生和功能恢复.
科学领域:
- 细胞的可塑性 细胞的可塑性
- 分子生物学分子生物学
- 神经科学是一个神经科学.
背景情况:
- 表皮-介质细胞过渡 (EMT) 对于发育,修复和转移至关重要.
- EMT是由信号通路,转录因子,表观遗传学和非编码RNAs来调节的.
- 周围神经系统中的 Schwann 细胞在受伤后表现出类似于 EMT 的转变.
研究的目的:
- 探索EMT类程序在神经再生期间在施万细胞中的作用.
- 突出针对外围神经损伤的 Schwann 细胞 EMT 的治疗潜力.
主要方法:
- 审查调节EMT的信号通路.
- 分析EMT的转录和表观遗传控制.
- 检查神经修复中的施万细胞功能的研究.
主要成果:
- 施万细胞在神经受伤后通过类似EMT的过程转化为修复细胞.
- 修复 施万细胞通过清除碎片,分泌因子和组织微环境,促进神经再生.
- 类似于EMT的程序调制是修复施万细胞功能的关键.
结论:
- 施万细胞中的类似EMT的程序对于外围神经再生至关重要.
- 针对这个程序为严重的神经损伤提供了一个有希望的治疗途径.
- 增强施万细胞修复表型可以改善神经损伤后的功能结果.
更多相关视频
相关概念视频
01:15Neurogenesis and Regeneration of Nervous Tissue
1.0K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.0K
01:29Somatic to iPS Cell Reprogramming
2.3K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.3K