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低骨密度的绝经后妇女的肠道微生物群变化与血清氨基酸代谢有关
Adriana Becerra-Cervera1,2, Rogelio F Jiménez-Ortega3,4, Diana I Aparicio-Bautista1
1Laboratorio de Genómica del Metabolismo Óseo, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico.
Frontiers in cellular and infection microbiology
|July 24, 2025
概括
肠道微生物群的组成和氨基酸水平与墨西哥妇女的低骨矿物质密度有关. 特定的细菌和改变的代谢途径可能会影响骨健康,表明潜在的治疗点.
科学领域:
- 微生物学 微生物学
- 骨的新陈代谢 骨的新陈代谢
- 营养科学 营养科学
背景情况:
- 肠道微生物群 (GM) 的改变与骨矿物质密度 (BMD) 的变化有关,可能会影响骨质疏松症和骨质疏松症.
- 关于肠道微生物群在墨西哥人口骨健康中的作用的数据有限.
- 绝经后的妇女特别容易失去骨密度.
研究的目的:
- 调查墨西哥绝经后妇女低BMD肠道微生物群的分类组成.
- 探索可能的连接肠道微生物群和骨代谢的机制.
- 分析血清氨基酸度的变化与BMD相关.
主要方法:
- 双能X射线吸收计 (DXA) 用于测量 BMD.
- 16S rRNA amplicon测序用于肠道微生物群的概况.
- PICRUSt2用于对代谢途径的功能预测.
- 串联质谱仪用于血清氨基酸量化.
主要成果:
- 在低BMD和正常BMD组之间观察到肠道微生物群β多样性的显著差异.
- 在低BMD的女性中,发现了特定细菌属 (例如,Bacteroides,Parabacteroides) 的丰度增加.
- 在低BMD组中发现了改变的代谢途径 (阿兰因,氨酸,白氨酸,氨酸) 和较低的氨酸,白氨酸和氨酸血清度.
结论:
- 在墨西哥绝经后妇女的肠道微生物群组成,氨基酸概况和BMD之间存在显著的关联.
- 特定的肠道细菌和改变的氨基酸代谢可能在骨密度调节中起作用.
- 这些发现表明了针对骨健康的治疗干预措施的新途径.
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