皮益善配方通过调节慢性病老鼠的肠道微生物群来改善功能
Yuzhi Wang1, Jiandong Lu2, Wenkui Dai3
1The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, China.
Frontiers in cellular and infection microbiology
|July 24, 2025
概括
吉安-皮--申配方 (JPYSF) 通过调节肠道微生物群 (GM) 在慢性病 (CKD) 的老鼠中降低了血清肌素. JPYSF选择性地增加了有益的肠道细菌,这表明通过转基因监管具有脏保护作用.
科学领域:
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 传统中医 (TCM) 和肠道微生物群 (GM) 之间的相互作用对于治疗效果至关重要.
- 建皮益申配方 (JPYSF) 在改善慢性病 (CKD) 症状方面显示出有前途.
- 在CKD中通过转基因调制对JPYSF的疗效的机制需要阐明.
研究的目的:
- 为了研究JPYSF对肠道微生物组合和功能在CKD的老鼠模型的影响.
- 探索JPYSF诱导的转基因变化与功能标志物之间的相关性.
主要方法:
- 小鼠使用腺素饮食诱导CKD,并用JPYSF治疗.
- 便样本在多个时间点收集,用于元基因组测序.
- 测量血清肌素 (SCR) 水平以评估功能.
主要成果:
- 与对照组相比,JPYSF治疗显著降低了CKD大鼠中SCR水平的升高.
- 氨酸诱导的CKD导致了转基因的显著转变,改变了共同丰富性相互作用组 (CIG).
- 治疗JPYSF导致CIG4的显著反弹,并减少了转基因不相似性,与改善的功能相关.
结论:
- JPYSF在CKD大鼠中显示出脏保护作用,这可能是通过选择性肠道微生物群调节的介导.
- 该配方似乎可以恢复有益的转基因模块,如CIG4,与尿素毒素通路相反相关.
- 这项研究强调了JPYSF通过肠道微生物组调节作为CKD治疗剂的潜力.
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