暴露于空气污染和早期青春期:一个系统的审查
Rosie Lee1, Jongmin Oh2,3,4, Eunji Mun1
1Department of Pediatrics, Ewha Womans University College of Medicine, Seoul, Korea.
Ewha medical journal
|July 24, 2025
概括
早期青春期的增长率可能与空气污染暴露有关. 这次审查发现了一些证据表明空气污染物加速青春期发育,但结果不一致,需要进一步研究.
科学领域:
- 环境健康 环境健康
- 儿科内分泌学 儿科内分泌学
- 流行病学 流行病学
背景情况:
- 全球早期青春期的发病率正在上升,与不良健康结果有关.
- 环境因素,包括空气污染,与遗传因素一起被怀疑是贡献者.
- 有限的流行病学数据表明,空气污染和青春期的时间之间存在潜在的联系.
研究的目的:
- 系统地审查和总结当前关于空气污染暴露与早熟青春期之间关系的证据.
- 巩固研究空气污染物和青春期发育的研究结果.
- 发现关于环境对青春期影响的研究中的差距.
主要方法:
- 在PubMed和Web of Science进行系统的文献搜索,直到2023年8月,遵守PRISMA指南.
- 包括的研究评估了空气污染物暴露和早期青春期,初潮或青春期发育的风险.
- 两个独立的审稿人进行了研究选择和数据提取;由于研究异质性和数量有限,元分析是不可行的.
主要成果:
- 从最初确定的184项研究中,包括了6项研究 (4374,074名参与者).
- 四项研究表明,更高的空气污染暴露与更早的青春期发作之间存在相关性.
- 一项研究得出了不确定的结果,另一项研究表明,随着空气污染物暴露,虫发病的延迟.
结论:
- 大多数研究表明,暴露于空气污染物可能会加速青春期的发展.
- 然而,跨研究的发现是不一致的,突出结果的变化.
- 进一步的大规模,精心设计的纵向研究是必要的,以建立对这种关联的最终理解.
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