持续高的Life's Essential 8与较低的脑小血管疾病风险有关:一个基于社区的研究
Huijing Shi1, Liufu Cui1, Ying Hui2
1Department of Rheumatology and Immunology, Kailuan General Hospital, Tangshan, China.
Frontiers in neurology
|July 24, 2025
概括
保持高的生命必需品8 (LE8) 评分与脑小血管疾病 (CSVD) 的风险降低有关. 这项研究表明,持续高的LE8得分可以防止CSVD的发展.
科学领域:
- 神经学 神经学
- 心血管健康 心血管健康
- 公共卫生 公共卫生
背景情况:
- 大脑小血管疾病 (CSVD) 是中风和认知障碍的主要原因.
- 生活必需品8 (LE8) 是心血管健康的一个关键指标.
- 了解LE8对神经疾病的长期影响至关重要.
研究的目的:
- 调查生活必需8 (LE8) 评分轨迹与患脑小血管疾病 (CSVD) 的风险之间的关联.
- 分析LE8得分的不同模式如何随着时间的推移影响特定的CSVD病变的存在.
主要方法:
- 利用Kailuan前性队列研究 (2006-2021) 中1,162名参与者的数据进行轨迹建模.
- 将参与者分为低,中,高稳定的LE8分数组.
- 采用后勤回归模型来评估LE8轨迹与CSVD总得分之间的关系,包括缺口性心脏病发作,大脑微型血流,白质超强度和扩大的周血管空间.
主要成果:
- 持续高的LE8得分与CSVD得分升高的风险有负相关性 (ORs:中等为0.65,高组为0.44与低组相比).
- LE8得分显著影响了缺口性心脏病发作,扩大周血管空间 (EPVS) 和白质超强度 (WMH).
- 没有观察到LE8得分对大脑微型血液 (CMB) 的统计学意义上的影响.
结论:
- 持续高的Life's Essential 8分数证明了对大脑小血管疾病的保护作用.
- 通过LE8指标保持最佳的心血管健康可能是预防CSVD的可行策略.
- LE8得分轨迹是特定的CSVD表现的重要预测因素,如缺口性心脏病发作,EPVS和WMH.
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