在舌头OSCC患者中WPOI和临床病理参数的相关性
Priyadharshini Muthumanickam1, Gheena Sukumaran1, Pratibha Ramani1
1Department of Oral Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
Journal of oral and maxillofacial pathology : JOMFP
|July 24, 2025
概括
在舌状细胞癌 (TSCC) 中最严重的入侵模式 (WPOI) 与晚期疾病和转移相关. Ki-67表达在攻击性TSCC中很高,有助于预后.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 口腔状细胞癌 (OSCC) 是一种常见的头癌.
- 舌头状细胞癌 (TSCC) 特别具有攻击性.
- 需要预后标志物来指导TSCC治疗.
研究的目的:
- 研究TSCC中最糟糕的入侵模式 (WPOI) 和Ki-67表达之间的相关性.
- 在TSCC中确定改善预后和治疗策略的标记物.
主要方法:
- 51个TSCC标本的回顾性分析.
- 通过免疫组织化学评估临床病理学数据,WPOI分类和Ki-67表达.
- 统计相关性分析.
主要成果:
- 观察到男性占主导地位 (平均年龄53岁).
- 高风险的WPOI模式与晚期疾病和转移有显著的相关性 (P < 0.001).
- 攻击性病例中平均Ki-67表达率为45%;没有发现显著的WPOI-外节延伸相关性.
结论:
- WPOI和Ki-67是TSCC攻击性的关键指标.
- 这些标志物有助于对个性化TSCC治疗的风险分层.
- 建议在更大的患者队伍中进一步验证.
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