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低密度中性粒细胞:理解口腔状细胞癌的瘤微环境的关键组成部分

Thayalan Dineshkumar¹, Nirmala Anandan², Rajkumar Krishnan¹

¹Department of Oral Pathology and Microbiology, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India.

Journal of oral and maxillofacial pathology : JOMFP

|July 24, 2025

概括

低密度中性粒细胞 (LDNs) 和正常密度中性粒细胞 (NDNs) 在口腔癌患者中显示出不同的比例. 这种LDN/NDN比率,以及中性粒细胞与淋巴细胞比率 (NLRs),可以作为口腔状细胞癌的诊断和预后标志物.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
癌症研究癌症研究

背景情况:

瘤微环境显著影响癌症的进展.
循环中的中性粒细胞,特别是低密度中性粒细胞 (LDNs),与瘤生长和转移有关.
在各种癌症中,LDN与疾病严重程度的增加有关.

研究的目的:

在口腔癌中研究LDN和正常密度中性粒细胞 (NDN) 的种群.
评估LDN/NDN比率和中性粒细胞与淋巴细胞比率 (NLRs) 作为口腔癌生物标志物的潜力.

主要方法:

涉及CD16+群体的磁性分类和白细胞密度梯度分离的前性研究.
使用流细胞计量来确定中性粒细胞亚种群的百分比.
确定了两个不同的人类中性粒细胞种群:LDN和NDN.

主要成果:

与对照组相比,口腔状细胞癌 (OSCC) 患者的LDN/NDN比率较高.
与LDN相比,OSCC患者的NDN百分比也较低.
在OSCC患者中观察到中性粒细胞与淋巴细胞比率 (NLR) 的升高.

结论:

在OSCC中,LDN/NDN比率具有显著的相关性,可以作为新疗法的基准.
LDN/NDN比率和NLR水平是OSCC患者预后和诊断的重要指标.

关键词:

低密度的中性粒细胞中性粒细胞中性粒细胞.正常密度的中性粒细胞.口腔状细胞癌的癌症.

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