在接受部手术的老年患者中,西普罗对术后痴呆的作用:一项随机对照试验
Zhen Chen1, Ying-Ying Liu1, Qian Hu1
1The First Clinical Medical College of Gannan Medical University, Ganzhou, Jiangxi, People's Republic of China.
Drug design, development and therapy
|July 24, 2025
概括
麻醉剂西普罗福尔在老年部手术患者中显示,手术后痴呆症 (POD) 的发生率较低,相比于普罗福尔. 沉默信息调节因子3 (SIRT3) 水平与POD相关,表明诊断潜力.
科学领域:
- 麻醉学 麻醉学
- 神经科学是一个神经科学.
- 老年病的医生 老年病的医生
背景情况:
- 齐普罗是一种新的静脉注射麻醉剂,临床使用越来越多.
- 西普罗和手术后妄 (POD) 之间的关联仍然不清楚.
- 沉默信息调节因子3 (SIRT3) 在神经元功能和线粒体健康中起作用.
研究的目的:
- 调查西普罗对POD病变发生的作用.
- 为了确定SIRT3表达是否与POD发展相关.
- 为了比较西普罗和普罗波麻醉之间的POD发病率.
主要方法:
- 一项随机对照双盲研究,涉及114名接受关节手术的老年患者.
- 患者被分配给接受西普罗 (0.3毫克/公斤) 或普罗波 (1.5毫克/公斤) 的麻醉诱导.
- 在手术后的第1天和第3天,使用3D-CAM尺度评估了手术后的妄想.
主要成果:
- 在西普罗组中,POD的发病率明显较低 (5.5%),相比于在普罗波组 (20%) (P = 0.022).
- 在术后第一天 (P = 0.028) 的西普罗组中,SIRT3表达更高,并且与POD相关.
- 在术后第一天的血清SIRT3水平显示POD的高诊断准确性 (AUC = 0.8540).
结论:
- 与propofol相比,西普罗与POD的发病率降低和血液循环效应最小有关.
- SIRT3表达与POD相关,表明其作为生物标记物的潜力.
- 血清SIRT3水平可以作为预测老年手术患者POD的诊断指标.
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