与代谢功能障碍相关的脂肪肝炎相关的肝细胞癌的发病和管理:叙述性综述
1Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
Ewha medical journal
|July 24, 2025
概括
代谢功能障碍相关的脂肪肝炎 (MASH) 正在导致肝癌 (HCC) 的增加. 改变生活方式和改善监测是预防和管理MASH相关的HCC的关键.
科学领域:
- 肝病学和瘤学 肝病学和瘤学
- 代谢障碍 代谢障碍 代谢障碍
- 癌症流行病学 癌症流行病学
背景情况:
- 代谢功能障碍相关的脂肪肝炎 (MASH) 是导致肝癌 (HCC) 的原因之一,与全球肥胖流行病有关.
- 预计到2030年,MASH相关的HCC (MASH-HCC) 将成为肝癌的主要驱动因素,这将带来重大的临床挑战.
- 目前,MASH-HCC占所有HCC病例的10%-20%,其发病率在全球范围内不断上升,特别是在西方国家.
研究的目的:
- 审查MASH-HCC的临床管理,包括当前的监测策略和治疗进展.
- 讨论管理MASH-HCC的挑战,并探索克服这些挑战的前景.
- 突出进一步研究分子驱动因素,预防疗法和MASH-HCC个性化治疗方法的需要.
主要方法:
- 文献综述检查了MASH-HCC的临床管理,监测和治疗.
- 对MASH-HCC的风险因素,病原和预防策略的分析.
- 讨论监测 (例如,肥胖患者的超声波敏感性) 和治疗 (例如,并发症,免疫治疗疗效) 的挑战.
主要成果:
- 肥胖是MASH和MASH-HCC的主要驱动因素.
- 风险因素包括肝硬化,糖尿病,肥胖,酒精,吸烟,遗传因素和微生物组变化.
- 有效的监测受到肥胖症的挑战,由于伴随疾病和潜在的免疫疗法差异,治疗需要量身定制的方法.
结论:
- 生活方式干预对于预防MASH至关重要.
- 改善监测和早期检测方法至关重要,但具有挑战性.
- 需要进一步的研究来确定分子驱动因素,开发预防疗法,完善监测和个性化MASH-HCC治疗,包括优化免疫疗法.
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