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有氧运动诱导的乳酸生产:为重塑瘤微环境提供了一个新的机会

Xin Zhou¹, Jinliang Jiang¹, Jingjing Liu¹

¹Graduate School of Education, Shandong Sport University, Jinan, Shandong, China.

Frontiers in genetics

|July 24, 2025

概括

有氧运动可以通过降低乳酸水平和抑制乳糖化来对抗癌症,乳糖化是一种推动瘤生长和在瘤微环境 (TME) 中抑制免疫力的过程. 这种方法增强了抗瘤免疫力,并提供了新的治疗策略.

科学领域:

在瘤学瘤学.
代谢途径代谢途径
免疫治疗是一种免疫疗法.

背景情况:

癌症对全球健康造成重大负担,瘤诱导的炎症阻碍了有效的治疗.
瘤微环境 (TME) 中乳酸水平升高,由华堡效应驱动,促进瘤的进展.
乳酸积累诱导乳化,这是一个翻译后的修改,增强了前瘤信号通路 (JAK-STAT,PI3K/Akt/mTOR) 并抑制了抗瘤免疫力.

研究的目的:

探索癌症中异常乳酸升高和乳糖化机制.
通过调节乳糖化来研究有氧运动作为预防瘤进展的干预措施的潜力.
通过检查有氧运动,乳和TME之间的相互作用来确定固体瘤的新型治疗标.

主要方法:

对有关乳酸代谢,乳化和瘤微观环境的现有文献的综述.
对有氧运动对乳酸清除和免疫细胞功能影响的分析.
探索瘤进展中的乳化驱动的表观遗传代谢相互作用.

主要成果:

在TME中的高乳酸盐水平促进乳化,导致免疫抑制和增强瘤生长.
有氧运动加速乳酸清除,降低TME乳酸度,缓解免疫抑制.
有氧运动增强了抗炎能力,并增强了抗瘤免疫细胞 (例如CD8+ T细胞) 的活性.

结论:

有氧运动可以通过降低乳酸水平和抑制乳糖化来抑制瘤的进展.
向乳化为固体瘤提供了一个有前途的治疗策略.
了解有氧运动和乳糖化之间的相互作用为癌症治疗提供了新的途径.

关键词:

华堡效应是什么? 华堡效应有氧运动是有氧运动.免疫细胞免疫细胞乳化乳化乳化瘤微环境是一个微环境.

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