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增强大脑DHA吸收的新方法:纳诺克洛普西斯微藻提取物的作用
Kunpeng Ma1, Shuhui Xie1,2, Ying Zhang3
1Interdisciplinary Center for Brain Information, the Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Frontiers in nutrition
|July 24, 2025
概括
含有lysodiacylglyceryltrimethylhomoserine (LDGTS) 的微藻油显著增加了大脑对多可萨赫萨酸 (DHA) 的吸收. 这种新的方法可以增强大脑功能,并通过提高DHA生物可用性来预防神经退行性疾病.
科学领域:
- 营养神经科学 营养神经科学
- 脂质代谢 脂质代谢是什么
- 生物化学 生化学
背景情况:
- 多可萨赫萨酸 (DHA) 对于大脑健康和预防神经系统疾病至关重要.
- 目前的DHA补充剂由于吸收有限,因此具有低于最佳的大脑生物可用性.
- Mfsd2a转运体促进大脑的DHA吸收,当它被化成lysophosphatidylcholine (LPC) 时.
研究的目的:
- 为了研究富含lysodiacylglyceryltrimethylhomoserine (LDGTS) 的Nanochloropsis微藻油是否可以增强大脑的DHA吸收.
- 评估LDGTS作为改善DHA生物可用性的潜在载体.
主要方法:
- 给小鼠各种脂质配方,包括微藻油和DHA-三糖醇 (TAG).
- 组织和器官样本在15天后被分析脂质和脂肪酸含量.
- 大脑的DHA摄入量被量化并与实验组进行了比较.
主要成果:
- 与TAG-DHA结合的微藻油与对照组相比,显著增加了大脑的DHA吸收.
- 单独TAG-DHA,单独微藻油或油都没有显示这种效果.
- DHA的结合增强了脑细胞生长和视网醇代谢途径,同时降低了细胞亡和炎症的调节.
结论:
- 富含LDGTS的微藻油显示出增强大脑中DHA生物可用性的承诺.
- 这代表了一种改善DHA补充疗效的新策略.
- 进一步的研究可能会验证微藻油作为优越的DHA输送系统.
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