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Updated: Sep 14, 2025

Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery
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Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery

Published on: April 17, 2012

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使用MALDI-TOF质谱仪快速识别达拉图穆马布干扰M蛋白检测:一个涉及脏轻链氨基粉症的案例研究

Hou-Long Luo1,2, Anping Xu1,2, Ling Ji1,2

  • 1Department of Laboratory Medicine, Peking University Shenzhen Hospital, 1120 Lianhua Road Futian, Shenzhen, Guangdong, 518036, PR China.

Practical laboratory medicine
|July 24, 2025
PubMed
概括

治疗性单克隆抗体,如达拉图穆马布,可以干扰血细胞疾病的诊断测试. 质谱法可以区分抗体和与疾病相关的蛋白质,防止误诊.

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相关概念视频

MALDI-TOF Mass Spectrometry01:19

MALDI-TOF Mass Spectrometry

Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.
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Peptide Identification Using Tandem Mass Spectrometry

Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
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