尿液挥发性有机化合物在预测慢性阻塞性肺病的风险在一个国家观察性研究
Shuojia Xie1,2, Junfeng Huang1, Gengjia Chen1,2
1Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. chen_rch@163.com.
Environmental science. Processes & impacts
|July 24, 2025
概括
尿液中的挥发性有机化合物 (VOC) 与慢性阻塞性肺病 (COPD) 风险增加有关. 这些化合物可以预测COPD的发展,可能通过炎症途径,根据NHANES数据分析.
科学领域:
- 环境健康 环境健康
- 呼吸系统医学 呼吸系统医学
- 生物标志物发现发现
背景情况:
- 慢性阻塞性肺病 (COPD) 是一个重要的全球健康问题.
- 遗传和环境因素有助于COPD,但尿液中挥发性有机化合物 (VOC) 的参与尚未得到充分了解.
研究的目的:
- 通过使用国家健康和营养检查调查 (NHANES) 数据,调查尿液VOC和COPD风险之间的关联.
- 探索尿液VOCs作为COPD预测生物标志物的潜力.
主要方法:
- 一项流行病学研究分析了来自782名参与者的NHANES数据 (2013-2018).
- 尿液VOC和COPD之间的关联使用后勤回归来评估.
- 通过接受器操作特征 (ROC) 和曲线下面面积 (AUC) 分析来评估诊断性能.
主要成果:
- 尿液中的7种VOC与COPD风险增加 (OR > 1,p < 0.05) 有统计学意义的关联.
- 观察到一种显著的剂量反应关系.
- 尿液中的VOCs通过炎症机制与COPD的发展有关.
- 组合的VOC模型实现了0.90的AUC,用于COPD预测.
结论:
- 在NHANES队列中,特定的尿液VOC与COPD风险增加之间存在明显的关联.
- 炎症途径可能是尿液VOC和COPD之间关系的关键调解者.
- 尿液中的挥发性有机化合物显示出可能成为COPD风险的有价值预测因素.
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