免疫检查点抑制剂相关心脏毒性的风险因素:范围审查
Yixuan Wang1, Liyan Zhang2, Zhenzhen Su1
1School of Nursing, Peking University, Beijing 100191, China.
The oncologist
|July 24, 2025
概括
免疫检查点抑制剂 (ICI) 心脏毒性,虽然很少见,但可能致命. 这次审查确定了60个风险因素,包括特定的风险因素,如心血管病史和病,以帮助早期检测和干预.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 的心脏毒性是癌症患者罕见但可能致命的并发症.
- 与ICI相关的心脏毒性的临床症状往往是非特异性的,阻碍了及时诊断.
- 识别高风险患者对于ICI治疗期间及时干预至关重要.
研究的目的:
- 确定与免疫检查点抑制剂 (ICI) 相关心脏毒性相关的风险因素.
- 为了能够早期识别患有ICI心脏毒性风险较高的患者群体.
- 为了为接受ICI治疗的患者提供及时干预.
主要方法:
- 根据Arksey和O'Malley框架进行了范围审查.
- 在十个主要的电子数据库中进行了系统的文献搜索.
- 数据选和提取由两位审查员独立进行,遵循PRISMA-ScR指南.
主要成果:
- 该审查确定了29项研究和60个与ICI相关的心脏毒性风险因素.
- 这些因素包括25种常见的免疫相关不良事件风险和5种传统的心血管疾病风险.
- 确定的特定危险因素包括心血管病史,病,阻塞性睡眠呼吸暂停,异常的实验室参数和心血管药物.
结论:
- 编制了60个风险因素的综合清单,涵盖了ICI相关心脏毒性的3个关键领域.
- 讨论了可能导致ICI心脏毒性的潜在潜在机制.
- 本综述为临床医生提供了工具,以识别有风险的患者,以改善预防,治疗和结果.
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