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瘤进展显示,在匹配的转移/初级阴膜黑色素瘤中,PD-L1表达的减少

Maria Chiara Gelmi¹, Gulçin Gezgin¹, Ellen Kapiteijn²

¹Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.

Acta ophthalmologica

|July 24, 2025

概括

转移性脑膜黑色素瘤 (UM) 的PD-L1表达率低,T细胞透率高于初级UM,这可能解释了对免疫检查点抑制剂 (ICI) 的反应不佳. 初级瘤可能会从ICI治疗中获益更多.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

免疫检查点抑制剂 (ICI) 已经改变了癌症治疗,但在转移性脑膜黑色素瘤 (UM) 中表现出有限的疗效.
了解UM中的瘤微环境对于改善ICI治疗结果至关重要.

研究的目的:

在初级和转移性UM中研究PD-1,PD-L1,T细胞和巨细胞标记物的表达.
阐明转移性UM患者对ICI的不满意反应背后的原因.

主要方法:

针对PD-L1,PD1,CD3,CD4,CD8,CD68,CD163,HLA I类和BAP1的32个UM样本 (13个初级,19个转移) 的免疫组织化学 (IHC) 染色.
标记物的定量和半定量评分以及初级和转移性UM之间的比较,包括匹配的情况.

主要成果:

与初级UM相比,转移性UM在瘤细胞上的PD-L1表达显著降低.
UM转移显示T细胞透率增加 (包括PD1表达),但巨细胞透率没有差异.
转移中的低HLA I类表达与缺席的PD-L1和PD1表达相关; BAP-1损失与更高的淋巴细胞透有关.

结论:

尽管淋巴细胞透量增加,但UM转移中的PD-L1表达率较低可能解释了ICI的有效性有限.
初级UM可能比转移更容易对ICI治疗做出反应.
在新辅助或辅助环境中准原发性瘤可能对高风险患者有益.

关键词:

免疫检查点是一个检查点.发生转移的转移.微观环境是一个微观环境.阴膜性黑色素瘤是什么

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