Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Abnormal Proliferation02:23

Abnormal Proliferation

4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
Tumor Progression02:07

Tumor Progression

6.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Blood-based kinase activity profiling to predict response to immune checkpoint inhibitors in patients with advanced stage NSCLC: the prospective IOpener study.

Journal for immunotherapy of cancer·2026
Same author

Response and survival in unresectable in-transit metastatic melanoma according to treatment strategy.

European journal of cancer (Oxford, England : 1990)·2026
Same author

Percutaneous hepatic perfusion versus best alternative care as treatment for metastatic uveal melanoma: A meta-analysis.

European journal of cancer (Oxford, England : 1990)·2026
Same author

Model-informed approaches to develop drug cost-saving dosing strategies for pembrolizumab.

European journal of cancer (Oxford, England : 1990)·2026
Same author

AI-based histopathology analysis predicts checkpoint inhibitor response in advanced melanoma and identifies patterns associated with response.

European journal of cancer (Oxford, England : 1990)·2026
Same author

Correction: Model‑Based Alternative Dosing Strategies for Subcutaneous Nivolumab to Improve Cost Effectiveness.

Clinical pharmacokinetics·2026
Same journal

En face localization of retinal telangiectatic capillaries using OCT compared with ICG angiography in chronic vascular macular oedema.

Acta ophthalmologica·2026
Same journal

Usher syndrome-related visual impairment in Finland: A 35-year nationwide register-based study (1985-2019).

Acta ophthalmologica·2026
Same journal

Three years of ocular proton therapy in the Netherlands, clinical results.

Acta ophthalmologica·2026
Same journal

Risk factors for acquisition and severity of Acanthamoeba and Fusarium keratitis in contact lens users-A case-control and clinical-epidemiological study, 2009-2020.

Acta ophthalmologica·2026
Same journal

Distinguish polypoidal choroidal vasculopathy through choroidal alterations: A systematic review, meta-analysis and narrative synthesis.

Acta ophthalmologica·2026
Same journal

Ocular blood flow and retinal oxygen saturation measurements in central retinal artery occlusion.

Acta ophthalmologica·2026
查看所有相关文章

相关实验视频

Updated: Sep 14, 2025

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
09:32

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Published on: February 8, 2018

14.8K

瘤进展显示,在匹配的转移/初级阴膜黑色素瘤中,PD-L1表达的减少.

Maria Chiara Gelmi1, Gulçin Gezgin1, Ellen Kapiteijn2

  • 1Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.

Acta ophthalmologica
|July 24, 2025
PubMed
概括
此摘要是机器生成的。

转移性脑膜黑色素瘤 (UM) 的PD-L1表达率低,T细胞透率高于初级UM,这可能解释了对免疫检查点抑制剂 (ICI) 的反应不佳. 初级瘤可能会从ICI治疗中获益更多.

关键词:
免疫检查点是一个检查点.发生转移的转移.微观环境是一个微观环境.阴膜性黑色素瘤是什么

更多相关视频

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
05:46

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

1.8K
Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
09:52

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Published on: January 25, 2015

13.5K

相关实验视频

Last Updated: Sep 14, 2025

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
09:32

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Published on: February 8, 2018

14.8K
Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
05:46

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

1.8K
Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
09:52

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Published on: January 25, 2015

13.5K

科学领域:

  • 在瘤学瘤学.
  • 免疫学 免疫学 免疫学
  • 病理学 病理学 病理学

背景情况:

  • 免疫检查点抑制剂 (ICI) 已经改变了癌症治疗,但在转移性脑膜黑色素瘤 (UM) 中表现出有限的疗效.
  • 了解UM中的瘤微环境对于改善ICI治疗结果至关重要.

研究的目的:

  • 在初级和转移性UM中研究PD-1,PD-L1,T细胞和巨细胞标记物的表达.
  • 阐明转移性UM患者对ICI的不满意反应背后的原因.

主要方法:

  • 针对PD-L1,PD1,CD3,CD4,CD8,CD68,CD163,HLA I类和BAP1的32个UM样本 (13个初级,19个转移) 的免疫组织化学 (IHC) 染色.
  • 标记物的定量和半定量评分以及初级和转移性UM之间的比较,包括匹配的情况.

主要成果:

  • 与初级UM相比,转移性UM在瘤细胞上的PD-L1表达显著降低.
  • UM转移显示T细胞透率增加 (包括PD1表达),但巨细胞透率没有差异.
  • 转移中的低HLA I类表达与缺席的PD-L1和PD1表达相关; BAP-1损失与更高的淋巴细胞透有关.

结论:

  • 尽管淋巴细胞透量增加,但UM转移中的PD-L1表达率较低可能解释了ICI的有效性有限.
  • 初级UM可能比转移更容易对ICI治疗做出反应.
  • 在新辅助或辅助环境中准原发性瘤可能对高风险患者有益.