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Updated: Sep 14, 2025

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克服E3酶介导抵抗:开发基于标记的新型疏水性降解剂,向ALK蛋白

Shaowen Xie1, Jingjie Zhu1, Fangyi Zhan1

  • 1Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu 211198, China.

Journal of medicinal chemistry
|July 24, 2025
PubMed
概括

新的疏水标签 (HyTs) 通过绕过E3结合酶来降解形淋巴瘤激酶 (ALK). 这种新的方法克服了耐药性,显示了针对ALK的精密瘤治疗的前景.

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