Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

5.7K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

AAVrh32.33 capsid demonstrates unexpected dermal tropism regardless of immunodominant epitope.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same author

A spatially coordinated keratinocyte-fibroblast circuit recruits MMP9<sup>+</sup> myeloid cells to drive type I interferon-driven inflammation in photosensitive autoimmunity.

Nature immunology·2026
Same author

Impact of treatment duration on response durability: A post hoc analysis of the double-blind, vehicle-controlled, randomized TRuE-V long-term extension study of ruxolitinib cream in vitiligo.

Journal of the American Academy of Dermatology·2026
Same author

Cancer-selective photoimmunotherapy spares T cells and NK cells and promotes antitumor immunity in an allogeneic human 3D culture model.

Photochemistry and photobiology·2026
Same author

Definition of Severity and Relapse for Vitiligo: An International Consensus Statement.

JAMA dermatology·2026
Same author

Prolonged ruxolitinib cream treatment for vitiligo among patients with no or limited response in the first 6 months.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026
Same journal

History and future of RNA medicines.

The Journal of investigative dermatology·2026
Same journal

A body-wide atlas for murine hair cycle dynamics.

The Journal of investigative dermatology·2026
Same journal

Clinical and molecular improvements in pediatric patients with atopic dermatitis treated with dupilumab: an analysis from the TREATKids registry.

The Journal of investigative dermatology·2026
Same journal

The genomic and spatial transcriptomic landscape of seborrheic keratoses.

The Journal of investigative dermatology·2026
Same journal

Introducing lesion-level metrics for melanocytic neoplasm clustering: Practical tools with potential applications in clinical practice.

The Journal of investigative dermatology·2026
Same journal

Reducing plastic waste in skin-model research: Sustainable packaging as a practical first step.

The Journal of investigative dermatology·2026
查看所有相关文章

相关实验视频

Updated: Sep 14, 2025

Direct Reprogramming of Mouse Fibroblasts into Melanocytes
09:38

Direct Reprogramming of Mouse Fibroblasts into Melanocytes

Published on: August 27, 2021

2.2K

解读色素减退:小鼠模型用于白风研究

Tyler J Long1, Todd F Pearson2, John E Harris2

  • 1Department of Dermatology, UMass Chan Medical School, Worcester, Massachusetts, USA; Department of Immunology, Morningside Graduate School of Biomedical Sciences, UMass Chan Medical School, Worcester, Massachusetts, USA.

The Journal of investigative dermatology
|July 24, 2025
PubMed
概括
此摘要是机器生成的。

本综述检查了小鼠模型的白风,一种导致脱色素的自身免疫性皮肤疾病. 了解这些模型对于开发新的白风治疗方法和推进研究至关重要.

关键词:
这是一种自身免疫力.临床研究是临床研究.模型 模型 模型鼠标 鼠标是一个鼠标.脊髓灰质炎 (Vitiligo) 是一种疾病.

更多相关视频

Studying Chronic Exposure of Mice to Ultraviolet B Radiation
03:20

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

Published on: August 19, 2025

978
Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research
10:10

Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research

Published on: November 2, 2018

9.4K

相关实验视频

Last Updated: Sep 14, 2025

Direct Reprogramming of Mouse Fibroblasts into Melanocytes
09:38

Direct Reprogramming of Mouse Fibroblasts into Melanocytes

Published on: August 27, 2021

2.2K
Studying Chronic Exposure of Mice to Ultraviolet B Radiation
03:20

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

Published on: August 19, 2025

978
Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research
10:10

Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research

Published on: November 2, 2018

9.4K

科学领域:

  • 皮肤病学 皮肤病学
  • 免疫学 免疫学 免疫学
  • 遗传学 是一个遗传学.

背景情况:

  • Vitiligo 是一种自身免疫性皮肤疾病,导致黑色素细胞的损失和脱色.
  • 临床前动物模型对于理解白风病原和开发治疗方法至关重要.

研究的目的:

  • 为已建立的白风小鼠模型提供全面的概述.
  • 根据黑色素细胞损失,免疫参与和人类疾病相关性的机制对这些模型进行分类.
  • 探索新兴的研究领域和对精细模型的需求.

主要方法:

  • 对已确定的白风小鼠模型的文献综述.
  • 基于疾病机制和相关性的模型分类.
  • 对现有的研究应用模型进行批判性评估.

主要成果:

  • 已建立的小鼠模型在它们的黑色素细胞损失和免疫参与机制上有所不同.
  • 目前的模型提供了对白风病原体的洞察,但在复制人类疾病异质性方面存在局限性.
  • 新兴研究强调了需要更复杂的模型.

结论:

  • 选择合适的小鼠模型对于推进白风研究至关重要.
  • 需要更精细的模型来更好地模仿人类白风,并预测治疗反应.
  • 临床前模型的持续开发将推动新的治疗策略.