空气污染混合物暴露与血蛋白在美国老年人小组中的关联
Ziyin Tang1, Ying Wang2, Jeremy A Sarnat1
1Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322 United States.
Environmental science & technology
|July 24, 2025
概括
空气污染显著改变老年人的循环蛋白质,影响免疫和信号通路. 这项研究突出了环境暴露对老年人蛋白质水平的慢性生物影响.
科学领域:
- 环境健康 环境健康
- 蛋白质组学是指蛋白质组学.
- 老年学是指老年学的学科.
背景情况:
- 空气污染对循环蛋白质的影响尚不清楚,特别是在老年人群中.
- 长期暴露于空气污染物可能会对脆弱群体产生重大生物学后果.
研究的目的:
- 研究空气污染物对老年人循环蛋白水平的单独和联合影响.
- 识别受空气污染暴露影响的特定蛋白质和生物通路.
主要方法:
- 利用了来自208名癌症预防研究II营养队列的老年参与者的血样本.
- 使用Olink平台测量了484种循环蛋白,并估计了空气污染物的暴露.
- 用于单个污染物的线性回归和污染物混合物的量子g计算,调整混因子和测试与吸烟状态的相互作用.
主要成果:
- 确定了167种与单个污染物或混合物相关的独特蛋白质 (p <0.05),其中15种符合误发现率<0.2.2.
- 观察到IL32,ADAM15和IL8与多个暴露指标的持续负相关性.
- 发现与污染物混合物和个人暴露相关的20种蛋白质,富含免疫和信号通路,在吸烟者中具有差异性关联.
结论:
- 对空气污染的暴露与老年人循环蛋白质特征的显著变化有关.
- 这些变化涉及免疫和信号通路,表明对环境污染物的慢性生物反应.
- 吸烟状态改变了空气污染和蛋白质水平之间的联系,强调了这些相互作用的复杂性.
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