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在接受降脂疗法治疗的HIV患者中,高灵敏度C反应蛋白和甘油三的升高

Anna Katrine Haslund Roed^1,2, Anne Marie Reimer Jensen^1,3,4, Andreas Dehlbæk Knudsen^1,2

¹Viro-immunology Research Unit, Department of Infectious Diseases 8632, Rigshospitalet, University of Copenhagen, Denmark.

AIDS (London, England)

|July 24, 2025

概括

接受降脂疗法 (LLT) 的艾滋病毒感染者 (PWH) 患有炎症和甘油三生物标志物升高的风险增加. 这凸显了对该人口中心血管疾病风险因素的更密切监测的必要性.

科学领域:

心脏病学心脏病学
传染性疾病传染性疾病
生物化学生物化学

背景情况:

艾滋病毒感染者 (PWH) 面临更高的心血管疾病 (CVD) 风险.
许多PWH接受降脂疗法 (LLT) 来控制脂质不良症.
与普通人群相比,在LLT上PWH的残留心血管疾病风险尚未得到充分理解.

研究的目的:

调查艾滋病毒感染与炎症和失脂血症生物标志物升高之间的关联.
为了比较PWH和接受LLT的一般人口控制之间的这些风险.
为了评估PWH的残留心血管风险,尽管LLT.

主要方法:

横截面研究比较COCOMO研究中的PWH和CGPS的控制.
频率匹配142 PWH和428对照对年龄和性别,所有在LLT.
用于分析生物标志物的多变量逻辑回归模型:hs-CRP,LDL-C和TG/HDL-C比率.

主要成果:

在LLT上的PWH具有显著更高的高灵敏性C反应蛋白 (hs-CRP) (aOR 1.97) 和甘油三 (TG) (aOR 3.36) 的风险.
两组之间没有观察到低密度脂蛋白胆固醇 (LDL-C) 风险的显著差异.
在灵敏度和子组分析中,研究结果很强大,除了基于蛋白酶抑制剂的疗法在PWH中的hs-CRP外.

结论:

与LLT的控制相比,在LLT上的PWH表现出较高的hs-CRP和TG升高的风险.
这些发现强调了提高警和优化治疗目标监测在LLT上的PWH的重要性.
可能需要进一步的研究来探索特定的抗逆转录病毒疗法对心血管风险标志物的影响.

关键词:

在C-反应性蛋白质中.在CRP中使用CRP.在CVD中,CVD是非常重要的.心血管疾病心血管疾病艾滋病病毒艾滋病病毒艾滋病病毒人类免疫缺陷病毒病毒.剩余的心血管风险剩余的心血管风险三甲酸甘油三甲酸甘油是什么

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