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Updated: Sep 14, 2025

Generation of Murine Cardiac Pacemaker Cell Aggregates Based on ES-Cell-Programming in Combination with Myh6-Promoter-Selection
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协调Tbx3/Tbx5成年心室导电系统的转录控制

Ozanna Burnicka-Turek1, Katy A Trampel2, Brigitte Laforest1

  • 1Departments of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, United States.

eLife
|July 24, 2025
PubMed
概括

T-box转录因子TBX3和TBX5对于心脏导电系统 (CCS) 的发展和功能至关重要. 它们的综合缺乏会破坏心室导电系统 (VCS),导致心律障碍.

关键词:
这就是T-box转录因子.在Tbx3中使用.Tbx3:Tbx5 双条件鼠标线路Tbx3:Tbx5缺乏的小鼠在Tbx5中使用.节律失常 节律失常心脏导电系统 (CCS) 是一种心脏导电系统.发育生物学是发展生物学.遗传学 遗传学 遗传学 是一个基因组学就是基因组学.心脏的节奏 节奏 心脏的节奏这里是鼠标鼠标鼠标鼠标鼠标鼠标.通过对VCS进行重新编程.腹腔导电系统 (VCS) 是一种心室导电系统.

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