美国印第安人中的A组链球菌,白山阿帕奇部落土地,美国,2016-2019年1
Emerging infectious diseases
|July 24, 2025
概括
甲型链球菌 (GAS) 在美洲印第安人群中引起严重的侵入性GAS感染. 这项研究跟踪了亚利桑那州的GAS emm类型和感染率,揭示了高疾病负担和需要干预的特定流行菌株.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 流行病学 流行病学
背景情况:
- 美国印第安人群体经历了不成比例的高率的侵袭性疾病由A组链球菌 (GAS) 引起.
- 了解GAS的流行病学和循环菌株对于在脆弱社区有效的公共卫生干预至关重要.
研究的目的:
- 描述严重和侵入性GAS (siGAS) 感染的发病率.
- 在不严重和siGAS病例中描述循环 emm 类型的分布.
- 在白山阿帕奇人群中为GAS疾病提供有针对性的干预信息.
主要方法:
- 在白山阿帕奇部落土地上 (2016-2019) 临床病例中的GAS分离物的回顾性分析.
- 采用全基因组测序来确定GAS分离物的emm类型.
- 分析了流行病学数据,包括患者人口统计和并发病例.
主要成果:
- 根据年龄标准化的siGAS发病率为每10万人中554.2 (2018-2019).
- 在siGAS病例中,36%是女性,中位数年龄为40.7岁,47.2%患有黄金葡萄球菌联合感染.
- 主要的emm类型有所不同; emm82最初在喉炎和siGAS病例中很常见,而 emm91在第二年的siGAS病例中占主导地位.
结论:
- 在这个美洲印第安人社区中,严重和侵入性GAS疾病的高发病率仍然存在.
- 特定的 emm 类型,如 emm82 和 emm91,是 GAS 感染的重要驱动因素.
- 迫切需要采取公共卫生干预措施,以减轻GAS疾病的负担.
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