少了就是多了吗? 在头部和部癌症中重复选择性节点辐射
M Haderlein1,2, C Frei3,4, T Weissmann3,4
1Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen Nürnberg, Universitätsstraße 27, 91054, Erlangen, Germany. marlen.haderlein@uk-erlangen.de.
概括
在头癌放射治疗中减少选择性节点辐射 (ENI) 显示出降级的前景. 虽然II期试验表明辐射场外的复发率较低,但III期试验结果尚未公布.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 医疗成像医学成像
背景情况:
- 放射治疗对于局部发达的头部和部状细胞癌 (HNSCC) 是至关重要的.
- 头部放射治疗会导致严重的急性和晚期副作用.
- 个性化放射治疗旨在降低毒性,同时保持疗效.
研究的目的:
- 对HNSCC在选择性淋巴排水区域的缓解辐射疗法的研究进行审查.
- 研究减少头癌治疗中辐射体积的方法.
主要方法:
- 在 MEDLINE, Web of Science 和 clinicaltrials.gov.gov 的文献搜索.
- 包括这些术语:头癌,选择性节点辐射,缓和,放射治疗.
- 排除了鼻癌和非状组织学.
主要成果:
- 方法包括剂量/体积减少或选择性节点辐射 (ENI) 的省略.
- 一些研究使用响应调整或缺氧引导调整.
- 第二阶段试验显示,在辐射场外的复发率很低 (高达4%).
结论:
- 减少或省略ENI是HNSCC的一个有希望的降级战略.
- 需要从III期试验中获得进一步的结果来确认疗效和安全性.
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