在雌激素缺乏的压力大鼠肠道微生物代谢轴的功能障碍
Rishabh Chaudhary1, Nitin Bansal2, Amanpreet Kaur3
1Department of Pharmacology, M. M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, 133207, Haryana, India.
Naunyn-Schmiedeberg's archives of pharmacology
|July 24, 2025
概括
在卵巢切除的老鼠中,雌激素缺乏和慢性压力会导致肠道失调和代谢功能障碍. 这种临床前模型揭示了肠道代谢轴的干扰,突出了绝经后妇女的潜在治疗点.
科学领域:
- 内分泌学 在内分泌学.
- 微生物学 微生物学
- 代谢健康 代谢健康
背景情况:
- 肠道失调 (不平衡的肠道微生物群) 与更年期雌激素损失后的代谢功能障碍有关.
- 荷尔蒙变化和压力可以加剧肥胖,脂质失调和糖尿病.
研究的目的:
- 创建一个临床前模型,研究雌激素缺乏和慢性不可预测的轻度压力 (CUMS) 对肠道微生物群和代谢功能障碍的影响.
- 阐明雌激素缺乏,压力状态中的生理,生化和分子变化.
主要方法:
- 卵巢切除术 (OVX) 的老鼠在28天内暴露在CUMS中.
- 评估了生理学,脂肪,人体,氧化应激和炎症标志物.
- 评估了肠道微生物群的组成,紧密结合蛋白,并对肝脏和结肠进行了组织病理学检查.
主要成果:
- OVX和CUMS诱导了生理变化,增加了脂肪,改变了人体标志物.
- 观察到肝脏,结肠和血清中氧化应激和炎症的增加.
- 发生了肠道失调,粘膜损伤,切断紧密的结节,肝脏和结肠的组织损伤.
结论:
- 雌激素缺乏和CUMS,单独和联合,破坏肠道代谢轴.
- 这种临床前模型证明了协同效应,有助于在绝经后状态下导致肠道和代谢功能障碍.
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