评估腹膜弹性层层侵袭,以改善pT3胃癌患者的分层
Daiki Terajima1,2,3, Motohiro Kojima4,2, Shingo Sakashita4,2
1Gastric Surgery Division, National Cancer Center Hospital East, Kashiwa, Japan.
概括
在胃癌 (GC) 中,弹性层层侵袭 (ELI) 显著恶化预后. ELI阳性pT3GC显示的生存率与pT4a相当,这表明需要重新评估当前的分期.
科学领域:
- 在瘤学瘤学.
- 手术病理学手术病理学
- 癌症预后 癌症预后
背景情况:
- 弹性层层侵袭 (ELI) 被定义为瘤侵袭腹膜弹性层之外的区域.
- 在胃癌 (GC) 中ELI的预后影响仍未得到充分研究.
研究的目的:
- 调查pT3或pT4a胃癌患者ELI和生存结果之间的关联.
主要方法:
- 从396名pT3或pT4aGC患者的病理幻灯片的回顾性审查,这些患者接受了治愈切除.
- 评估ELI状态与无复发生存率 (RFS) 和总生存率 (OS) 之间的相关性.
主要成果:
- 对ELI阴性pT3GC的5年RFS为85.9%,对ELI阳性pT3的55.9%,对pT4aGC的51.3%.
- 对于ELI阴性pT3 GC的5年生存率为90.4%,对于ELI阳性pT3为67.0%,对于pT4a GC为63.6%.
- 多变量分析确定了ELI状态,瘤大小和结节转移作为RFS的显著预后因素.
结论:
- 有ELI的pT3GC表现出较差的预后,类似于pT4aGC.
- 这些发现表明,可能需要修改胃癌目前的pT分级系统.
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