从机制到疾病:心脏代谢疾病中的酸盐-GPR91轴
1Department of Nutrition and Food Hygiene, School of Public Health, Capital Medical University, Beijing, China.
Journal of cardiovascular translational research
|July 24, 2025
概括
顺酸-GPR91通路通过促进炎症和心脏功能障碍,与心脏代谢疾病 (CMD) 有关. 针对这种代谢途径可能为心血管和代谢疾病提供新的治疗策略.
科学领域:
- 生物化学 生物化学
- 心脏病学 心脏病学
- 代谢研究研究 代谢研究
背景情况:
- 心脏代谢性疾病 (CMD) 涉及与肥胖和糖尿病等代谢问题相关的心血管疾病.
- 关键的病理机制包括慢性炎症,心肌缩和线粒体功能障碍.
- 顺酸-GPR91通路正在成为代谢调节和疾病的重要因素.
研究的目的:
- 审查酸盐-GPR91通路在心脏代谢疾病的发病过程中的作用.
- 通过GPR91.1.通过GPR91.1.通过GPR91.1.通过GPR91.1.探索酸盐作为代谢中间体和信号分子的功能.
- 讨论针对新型CMD疗法的这种途径的潜力.
主要方法:
- 对苏酸盐,GPR91和心脏代谢疾病的研究进行文献综述.
- 对酸盐在炎症,心肌缩和线粒体功能障碍中的参与进行分析.
- 综合目前关于代谢障碍和心血管损伤中的糖酸盐-GPR91轴的研究.
主要成果:
- 顺酸-GPR91轴的异常激活与肥胖,高血压,糖尿病和动脉样硬化有关.
- 这个轴加剧炎症,加速心肌缩,并诱导线粒体功能障碍,导致心血管损伤.
- 苏酸盐通过GPR91作为信号分子,影响病理生理过程.
结论:
- 酸盐-GPR91通路在心脏代谢疾病的发展和进展中发挥着关键作用.
- 向苏酸盐-GPR91轴为CMD提供了一个有前途的治疗途径.
- 对这种途径的进一步研究可以为CMD治疗策略提供有价值的见解.
相关概念视频
01:27Transducer Mechanism: Enzyme-Linked Receptors
2.8K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
2.8K
01:17Pathophysiology of Heart Failure
1.8K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.8K
01:15G Protein-coupled Receptors
13.5K
G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
13.5K
01:28Mechanism of Cardiac Arrhythmias
1.1K
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
1.1K
01:29Heart Failure II: Pathophysiology
44
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
44
01:48ATP Synthase: Mechanism
15.2K
In animals, the mitochondrial F1F0 ATP synthase is the key protein that synthesizes ATP molecules through a complex catalytic mechanism. While the nuclear genome encodes the majority of ATP synthase subunits, the mitochondrial genome encodes some of the enzyme's most critical components. The formation of this multi-subunit enzyme is a complex multi-step process regulated at the level of transcription, translation, and assembly. Defects in one or more of these steps can result in decreased...
15.2K