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血清胆汁酸概况的潜在诊断价值在女孩中部早期青春期

Shan Wang¹, A Na Liu¹, Xin-Yi Liang¹

¹Department of Endocrinology, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China.

World journal of pediatrics : WJP

|July 24, 2025

概括

胆酸概况可以帮助诊断女孩的中心早熟青春期 (CPP),为当前的测试提供一种不那么侵入性的替代方案. 特定的胆酸特征显示出作为CPP的诊断生物标志物具有前途.

科学领域:

内分泌学在内分泌学.
代谢学代谢学代谢学
儿科内分泌学儿科内分泌学

背景情况:

中部早发性青春期 (CPP) 诊断依赖于侵袭性淋巴激素释放激素刺激试验.
胆汁酸 (BAs) 越来越多地被认为是它们在生殖系统信号传递中的作用.

研究的目的:

为了确定循环胆汁酸 (BA) 形状的特征,用于诊断女孩中部早熟性青春期 (CPP).
探索BA资料作为CPP的非侵入性生物标志物的潜力.

主要方法:

431名女孩被录取,分为培训和验证队伍.
血清样本使用超高性能液体染色学-并联质谱学进行分析,以量化38个BA.
参与者按体重指数Z-score和CPP诊断进行分组.

主要成果:

18个个别的BA在CPP和非CPP组之间存在显著差异.
大多数不同的BA (14/18) 与与性相关的激素相关.
结合特定BA的模型实现了高诊断准确性 (正常体重AUC为0.885,超重/肥胖女孩AUC为0.914).

结论:

血清BA型号在CPP女孩中显著改变,与性激素水平相关.
BA 档案显示出其作为 CPP 的诊断和查生物标志物的潜力.
这些发现表明一种新的,不那么侵入性的方法来诊断CPP.

关键词:

胆酸是什么意思胆酸是什么意思中心早熟青春期中心早熟青春期诊断诊断诊断诊断诊断血清中的生物标志物有针对性的代谢组学.

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