基托醇糖类通过减少肠粘膜损伤和调节肠道微生物群来改善严重的急性胰腺炎
Fanjun Meng1, Guangchen Sun1, Yan Zhao2
1Department of Gastroenterology, General Hospital of Northern Theatre Command, 83 Wenhua Road, Shenyang, Liaoning, 110840, China.
Probiotics and antimicrobial proteins
|July 24, 2025
概括
基托酸糖 (COS) 通过改善肠道屏障功能和微生物群平衡,在治疗严重急性胰腺炎 (SAP) 方面表现有前途. 这项研究证明了COS COS.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 微生物学 微生物学
- 生物化学 生物化学
背景情况:
- 严重急性胰腺炎 (SAP) 是一种具有高死亡率的严重疾病,其特征是炎症和器官功能障碍.
- 目前SAP的治疗选择有限,其致病性并未完全理解.
- 奇多糖 (COS),一种天然的糖,具有抗炎,抗氧化和肠道微生物群调节的特性.
研究的目的:
- 在严重急性胰腺炎 (SAP) 的小鼠模型中,研究基托醇糖 (COS) 对肠道粘膜屏障和微生物群的保护作用.
- 阐明COS在SAP中的治疗潜力背后的抗炎和抗氧化机制.
- 在SAP中评估COS对肠道完整性,炎症,氧化应激和肠道微生物组成的影响.
主要方法:
- 一种严重的急性胰腺炎 (SAP) 鼠标模型是通过注射黄酸盐到胰腺胆道诱导的.
- 动物接受了不同度的基托醇糖 (COS) 治疗.
- 评估包括血清生物标志物,炎症和氧化应激标志物,肠道透性,E-cadherin和ZO-1的蛋白质表达,用于肠道微生物群分析的16SrRNA测序,以及肠道炎症的体外细胞模型.
主要成果:
- 在SAP大鼠中,基托醇糖 (COS) 治疗显著降低了血清胰腺炎生物标志物和炎症因素.
- COS改善了胰腺和肠道组织病理学,降低了肠道炎症和血肠道透性,并增强了抗氧化能力.
- COS上调调节了E-cadherin和ZO-1的表达,表明肠道屏障完整性恢复,以及调节了肠道微生物群的组成和平衡.
结论:
- 甲基氧糖 (COS) 通过恢复肠道屏障功能和重新平衡肠道微生物群来改善严重的急性胰腺炎 (SAP) 的严重程度.
- COS具有显著的抗炎和抗氧化作用,有助于其在SAP中的保护作用.
- 这些发现表明,基托醇糖 (COS) 具有作为严重急性胰腺炎 (SAP) 的治疗剂的潜力,需要进一步的临床研究.
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