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初级卵巢衰竭和卵巢储备不足的细胞疗法:系统性审查
Burakhan Seyihoglu1, Sude Gucuk1, Alp Can2
1Laboratories for Stem Cells and Reproductive Cell Biology, Department of Histology and Embryology, Ankara University School of Medicine, Sihhiye, Ankara, 06230, Turkey.
Journal of assisted reproduction and genetics
|July 24, 2025
概括
细胞疗法对原发性卵巢缺陷 (POI) 和卵巢反应不良 (POR) 有望,报告了一些怀孕. 然而,研究的局限性要求进行更大的试验,使用标准化方案,以获得可靠的疗效和安全数据.
科学领域:
- 生殖医学和内分泌学.
- 细胞和再生医学是细胞和再生医学.
背景情况:
- 初级卵巢缺陷 (POI) 和卵巢反应不良 (POR) 显著影响生育能力和生活质量.
- 细胞疗法,特别是使用介质干细胞/细胞 (MSCs),正在作为一种新的治疗方法进行探索.
研究的目的:
- 批判性地评估细胞疗法在管理POI和POR中的有效性,安全性和局限性.
- 综合临床试验和试点研究对卵巢功能障碍的细胞治疗的现有证据.
主要方法:
- 在主要数据库 (PubMed,Scopus,Web of Science,Cochrane) 进行了全面的文献搜索.
- 包括的研究仅限于人类临床试验,试点研究和从2014年起出版的病例报告.
- 排除包括动物实验,体外研究和非临床研究设计;分析了27项涉及694名患者的研究.
主要成果:
- 大多数研究 (59.3%) 来自亚洲,很大一部分 (77.8%) 缺乏对照组.
- 自主骨髓MSCs,通常与富血小板血相结合,经常被使用 (51.8%).
- 经过阴道或腹腔镜的卵巢内注射是常见的;接受治疗的患者怀孕率为11.7%,对照患者为7.6%,月经恢复率为7.1%.
结论:
- 样本大小和方法的显著变化阻碍了当前研究结果的可靠性.
- 针对细胞类型,输送方法和结果评估的标准化协议对于未来的研究至关重要.
- 7-12个月的随访似乎足够有效,但可能不足以进行全面的安全评估;患者分层可能会提高结果.
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