脊椎病理学,0.04%的氨酸和0.01%的氨酸用于近视控制:一项随机临床试验
Hannan Xu1,2, Moxin Chen3,4, Luyao Ye5
1Department of Preventative Ophthalmology, Shanghai Eye Diseases Prevention & Treatment Center/Shanghai Eye Hospital, National Clinical Research Center for Eye Diseases, Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases, School of Medicine, Tongji University, Shanghai, China.
JAMA ophthalmology
|July 24, 2025
概括
在8至15岁的儿童中,0.04%的阿特罗平有效控制了近视,超过了0.01%的阿特罗平和orthokeratology. 虽然0.04%的氨酸显示出卓越的疗效,但它也增加了光恐惧症的风险,需要仔细考虑近视管理.
科学领域:
- 眼科医生 眼科 眼科
- 儿科光学测量 儿科光学测量
- 临床试验研究 临床试验研究
背景情况:
- 控制近视对于儿童和青少年至关重要,以防止长期视力损伤.
- 脊椎病理学和低剂量氨酸是确立的近视控制策略.
- 优化治疗的有效性和安全性需要比较不同年龄组的不同干预措施.
研究的目的:
- 为了比较0.04%的阿特罗平,0.01%的阿特罗平,和orthokeratology在控制近视进展的有效性和安全性超过两年.
- 评估8至15岁儿童和青少年的治疗结果.
主要方法:
- 一个三臂,并行设计,多中心随机临床试验,涉及209名近视 (-1.0D至-4.0D) 的儿童 (8-15岁).
- 干预措施包括每天0.01%或0.04%的氨酸,或在2年内进行一夜间的脊髓炎治疗.
- 测量的主要结果是2年期间轴长 (AL) 的变化.
主要成果:
- 与0.01%的阿特罗平 (0.18毫米差异,P<.001) 相比,0.04%的阿特罗平显著降低了AL的增加.
- 在临床上有意义的,虽然不是统计学上显著的,在AL减少的差异观察到0.01%的阿特罗平和脊髓瘤学 (0.08毫米的差异,P=.04).
- 年龄较大与AL增长较少相关,而较高的基线近视预测与脊椎病理学较慢的延长. 摄影恐惧在0.04%的阿特罗平 (22.9%) 时比0.01%的阿特罗平 (2.1%) 更频繁.
结论:
- 在这个队列中,0.04%的阿特罗平与0.01%的阿特罗平和orthokeratology相比,显示出更高的近视控制功效.
- 摄影恐惧症的风险增加与0.04%的阿特罗值得考虑在治疗决策.
- 建议进行长期跟踪,以充分评估这些近视控制干预措施的持续效果和安全性.
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