梅克利辛的使用和随后的病例在头患者中出现
Meredith E Adams1,2, Pinar Karaca-Mandic3, Schelomo Marmor1,4,5
1Department of Otolaryngology-Head and Neck Surgery, University of Minnesota, Minneapolis.
JAMA otolaryngology-- head & neck surgery
|July 24, 2025
概括
梅克利辛是一种常见的头药物,与所有年龄段的成年人中跌倒风险的增加有关. 这项研究表明,停止其常规使用可能是必要的,以提高患者的安全性和减少跌倒.
科学领域:
- 临床医学 临床医学
- 药理学 药理学是指药理学的学科.
- 老年病的医生 老年病的医生
背景情况:
- 头是成年人常见的抱怨,需要识别和取消低价值护理的实施,以减轻跌倒风险.
- 梅克利辛是一种具有抗胆固醇特性的抗组胺,在美国经常被处方为抗的前庭抑制剂.
研究的目的:
- 调查使用麦克利辛和随后的伤害性跌倒在18至64岁的成年人以及被诊断患有头的65岁或以上的成年人之间的关联.
- 评估影响梅克利津处方模式的因素及其与秋季结果的相关性.
主要方法:
- 一项回顾性队列研究利用美国商业和医疗保险优势索赔数据从2006年到2015年.
- 包括805,454名新诊断为头的成年人,分析了在30天内处方的麦克利辛,并在处方后60天内处方.
- 使用多变量分析来估计相关性,并根据社会人口统计学和临床因素进行调整.
主要成果:
- 在805,454名头的成年人中,有8%接受了梅克利辛的处方.
- 梅克利辛的使用与年轻人 (18-64岁;HR,2.94) 和老年人 (≥65岁;HR,2.54) 伤害性跌倒的风险增加有关.
- 约有9%的服用梅克利辛的患者在处方后60天内出现了伤害性跌倒.
结论:
- 治疗头的梅克利辛处方与所有成年年龄组的伤害性跌倒风险显著增加有关.
- 目前用于治疗头的梅克利辛似乎与指导方针一致的护理不一致,突出了需要取消实施策略的需要.
- 对前体抑制剂和跌倒风险的进一步研究是有必要的,这可能会导致更新的临床指南.
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