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人体下肠的衰老 人体下肠的衰老
Nicholas Baidoo1,2, Gareth J Sanger2
1University of Westminster, School of Life Sciences, London, UK.
概括
衰老导致下肠退行性变化,增加便秘和失禁的风险. 老年人肠道屏障功能减弱和神经肌肉活动减少肠道储备,使他们更容易受到肠道功能障碍的影响.
科学领域:
- 胃肠病学 胃肠病学
- 老年学是指老年学的学科.
- 细胞生物学 细胞生物学
背景情况:
- 老年人患上胃肠道疾病的患病率更高,例如慢性便秘和便失禁.
- 下肠的与年龄相关的变化对这些情况有很大影响.
研究的目的:
- 审查人类下肠道与年龄相关的退行性变化.
- 了解老年人胃肠道疾病增加背后的机制.
主要方法:
- 对有关结肠与年龄相关的变化现有文献的综述.
- 分析衰老胃肠道细胞和功能变化的分析.
主要成果:
- 减少腹部疼痛感知和较低的发病率的一些肠-大脑疾病在老年人.
- 粘膜屏障功能的年龄相关下降,原因是干细胞活性降低,紧密结合蛋白和粘液.
- 结肠的退行性变化,特别是上升结肠,与降低胆性神经肌肉功能和结肠运动能力受损.
- 老年人"肠道储备"能力降低,增加因外部因素导致肠道功能障碍的易感性.
结论:
- 与年龄相关的变化损害了下肠的结构完整性和功能能力.
- 这些退行性过程显著增加了老年人患上便秘和失禁等胃肠道症状的可能性.
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