巴西的状细胞病死亡率
Paula Fraiman Blatyta Caselli1, Claudia Di Lorenzo Oliveira2, Isabel Gomes3
1Faculdade Israelita de Ciências da Saúde Albert Einstein (FICSAE), São Paulo, Brazil.
PLOS global public health
|July 24, 2025
概括
巴西的状细胞病患者面临过早死亡,主要原因是感染和器官损伤. 关键的死亡预测因素包括老年,铁过载和住院,需要有针对性的干预措施.
科学领域:
- 血液学 血液学 血液学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 状细胞疾病 (SCD) 仍然是一个重大的健康问题,尽管医学进步,死亡率高于一般人群.
- 在巴西,了解SCD死亡率模式对于公共卫生战略至关重要.
研究的目的:
- 评估巴西SCD队列中死亡率的原因和独立预测因素.
- 确定导致状细胞病患者过早死亡的因素.
主要方法:
- 对包括2,793名SCD患者在内的多中心REDS-III队列数据 (2013-2018) 的分析.
- 使用统计测试和多变量考克斯回归来确定死亡率预测因子的已故和幸存患者的比较.
- 通过查看图表和链接国家死亡证明来确认死亡.
主要成果:
- 总共有159人死亡 (5.7%),平均预期寿命为65.7年.
- 感染 (33.3%),非传染性肺部疾病 (25.2%) 和神经疾病 (14.5%) 是导致死亡的主要原因.
- 成年人死亡率的独立预测因素包括年龄较大,铁过载和先前入院.
结论:
- 巴西SCD患者的死亡率比一般人群早大约10年.
- SCD死亡率的负担越来越多地影响着成年人,特别是在他们的第三和第四十年.
- 迅速管理感染,急性胸部综合征,中风,铁过载和频繁住院治疗对于改善SCD的生存率至关重要.
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