相关实验视频

Updated: Sep 14, 2025

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
07:59

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

Published on: March 25, 2014

15.1K

对MHC-I复合物的高特异性结合剂的设计

Bingxu Liu1,2, Nathan F Greenwood1,2, Julia E Bonzanini1,2,3

  • 1Department of Biochemistry, University of Washington, Seattle, WA, USA.

Science (New York, N.Y.)
|July 24, 2025
PubMed
概括

科学家通过识别特定的MHC-I (pMHCI) 复合体来设计针对病细胞的新型蛋白质. 这些工程结合剂在仿真抗原受体中使用时成功激活T细胞,显示出新的癌症疗法潜力.

更多相关视频

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis09:32

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis

Published on: October 15, 2021

12.9K
Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay19:05

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay

Published on: October 30, 2015

12.5K

相关概念视频

Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
13.2K