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Updated: Sep 14, 2025

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新设计的pMHC结合剂促进T细胞对癌细胞的中介性细胞毒性

Kristoffer Haurum Johansen1, Darian Stephan Wolff2, Beatrice Scapolo1,2

  • 1Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.

Science (New York, N.Y.)
|July 24, 2025
PubMed
概括

研究人员使用生成模型开发了一个新的平台,用于设计针对癌症特异性T细胞受体 (TCR) 的小型结合剂. 这种方法成功地制造出一种高亲和度的结合剂,从而杀死黑色素瘤细胞,并显示出精确免疫治疗的前景.

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