相关实验视频

Updated: Sep 14, 2025

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
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Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

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ExcludonFinder:绘制邻近基因之间的转录重叠

Álvaro Sanmartín1, Pablo Iturbe1, Jerónimo Rodríguez-Beltrán2,3

  • 1Laboratory of Microbial Pathogenesis, Navarrabiomed-Universidad Pública de Navarra (UPNA)-Complejo Hospitalario de Navarra (CHN), IdiSNA, Irunlarrea 3, Pamplona, 31008 Navarra, Spain.

Nucleic acids research
|July 24, 2025
PubMed
概括

细菌使用重叠的基因转录,形成排斥子,以控制基因表达. 这项研究对大肠杆菌和金黄色杆菌中的这些排斥物进行了映射,揭示了它们在细菌基因调节中的广泛作用.

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The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
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Transposons, or "jumping genes," are small mobile genetic elements (MGEs) that range from 700 to 40,000 base pairs in length. They are found in all organisms and can move within the same chromosome or transfer to different chromosomes. In some cases, transposons can also jump between different host DNA molecules, such as plasmids or viruses, contributing to genetic variability.Barbara McClintock first discovered these mobile genetic elements in the 1940s while studying maize genetics, and she...
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