精神分裂症中的REM睡眠:系统性审查和元分析
Dario Morra1, Giuseppe Barbato1
1Università degli Studi della Campania "Luigi Vanvitelli" - Department of Psychology, Viale Ellittico 31, Caserta, Italy.
Sleep medicine reviews
|July 24, 2025
概括
与健康人相比,精神分裂症患者表现出改变的快速眼动 (REM) 睡眠,减少REM时间和缩短REM延迟时间. 抗精神病治疗可以使一些REM睡眠特征正常化,但不能使REM密度正常化.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 睡眠医学 睡眠医学
背景情况:
- 精神分裂症是一种复杂的精神障碍,与各种神经生物学异常有关.
- 睡眠障碍,特别是快速眼动 (REM) 睡眠,在精神分裂症中经常被报告.
- 了解REM睡眠变化可能会为精神分裂症的病理生理学和治疗提供洞察力.
研究的目的:
- 系统地审查和对精神分裂症患者的REM睡眠参数进行元分析.
- 为了比较精神分裂症患者的REM睡眠发现 (无药,无药,接受治疗) 与健康对照和抑郁患者.
- 为了研究抗精神病治疗对REM睡眠的影响.
主要方法:
- 从1955年到2025年发表的研究的系统审查和元分析.
- 包括92项病例对照研究,涉及1845名精神分裂症患者,1269名健康对照和262名抑郁症患者.
- 使用随机效应模型分析REM睡眠参数,包括REM时间,百分比,延迟和密度.
主要成果:
- 与健康对照组相比,精神分裂症患者的REM时间缩短,REM延迟缩短.
- 在未服用药物和接受治疗的精神分裂症患者中,REM密度增加.
- 在精神分裂症患者和健康对照人群之间没有观察到REM百分比的显著差异.
- 精神分裂症患者的REM延迟减少类似于抑郁症患者的REM延迟.
- 抗精神病治疗似乎能使REM时间和REM延迟正常化,但不能使REM密度正常化.
结论:
- 精神分裂症的特点是特定的REM睡眠异常,包括减少REM时间和延迟,增加REM密度.
- 精神分裂症的REM睡眠变化与抑郁症的REM睡眠变化有相似之处,特别是在REM延迟方面.
- 抗精神病药物可能部分使REM睡眠正常化,但REM密度表明不同的潜在机制可能独立于REM发生调节.
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