在情绪阶段跨越双极性疾病的睡眠异常:一个系统的审查和元分析
Mattia Marchetti1, Ahmad Mayeli2, Claudio Sanguineti3
1Department of Health Sciences, University of Milan, Milan, Italy.
Sleep medicine reviews
|July 24, 2025
概括
睡眠问题在双相情感障碍 (BD) 中很常见. 睡眠质量差影响了52%的euthymic个体,而失眠影响了63%的抑郁阶段,需要量身定制的管理.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 睡眠医学 睡眠医学
背景情况:
- 睡眠异常是双相情感障碍 (BD) 的核心特征.
- 以前的研究还没有彻底检查BD中不同情绪阶段的睡眠障碍.
- 了解这些变异对于有效的患者管理至关重要.
研究的目的:
- 在不同情绪阶段调查两极性障碍中睡眠障碍的患病率.
- 为了比较BD个体与不同情绪状态的对照个体之间的睡眠特征.
- 突出综合睡眠评估方法的重要性.
主要方法:
- 对44项涉及7614例BD病例和3164例对照的研究进行了系统的元分析.
- 包括到2024年9月发表的流行和病例控制研究.
- 分析了睡眠质量,失眠和客观睡眠参数 (总睡眠时间,睡眠开始延迟,REM百分比,睡眠效率).
主要成果:
- 睡眠质量差的患病率是52%在euthymia;失眠的患病率是63%在抑郁期.
- 与对照组相比,Euthymic BD患者报告睡眠质量较差,客观测量总睡眠时间和睡眠开始延迟时间比对照组更长.
- 抑郁阶段的BD显示出更高的REM百分比;躁狂/混合阶段的BD显示出更短的总睡眠时间,更低的睡眠效率和更长的睡眠开始延迟.
结论:
- 睡眠质量差和失眠在双相情感障碍的整个过程中非常普遍.
- 在euthymia,抑郁和躁狂阶段存在明显的睡眠参数差异.
- 综合的客观和主观睡眠评估对于在BD中量身定制的睡眠问题的管理至关重要.
相关概念视频
Bipolar Disorder
144
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
144
Mania and Antimanic Drugs: Overview
321
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
321
Management of Insomnia
323
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
323
Depression: Overview
343
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
343
Sleep-Wake Cycles
1.6K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.6K
Substance Use Disorders Affecting Sleep
217
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
217


