乙醇脂和脂驱动性别特异的人体衰老动态
Joaquim Sol1, Anna Fernàndez-Bernal2, Natalia Mota-Martorell2
1Department of Experimental Medicine, University of Lleida-Lleida Biomedical Research Institute (UdL-IRBLleida), Lleida, Spain; Catalan Health Institute (ICS), Primary Care, Lleida, Spain.
Redox biology
|July 24, 2025
概括
衰老显著改变脂质代谢,在男性和女性中观察到不同的模式. 这项研究揭示了与年龄相关的脂质变化,为健康衰老生物标志物和干预措施提供了洞察力.
科学领域:
- 老年学是一门学科.
- 代谢学 代谢学 代谢学
- 利皮多米克 (Lipidomics) 是一种消化剂.
背景情况:
- 衰老涉及复杂的分子变化,包括脂质代谢的改变.
- 了解与年龄相关的脂质组动态和性别特异性特征对于健康衰老研究至关重要.
研究的目的:
- 系统地定义整个生命周期的脂质组动态.
- 为了识别与衰老相关的性别特异性脂质体特征.
- 为了研究与年龄相关的脂质转移的功能影响.
主要方法:
- 从1030名成年人 (年龄在50-98岁之间) 的血中进行向性脂质基因分析.
- 使用质谱学和气相色谱学分析了543种脂质物种和循环脂肪酸成分.
- 识别与年龄相关的脂质体变化和性别特异性模式.
主要成果:
- 在脂质代谢中观察到与年龄相关的显著变化,特别是影响胺和以太结合脂.
- 确定了三个不同的衰老峰值 (55-60,65-70,75-80岁),65-70 (男性) 和75-80 (女性) 年龄峰值中性别特异性占主导地位.
- 脂质丰富分析揭示了乙卡尼丁,脂和以太结合的脂作为关键贡献者,表明脂质功能类别受损.
结论:
- 脂质新陈代谢在衰老过程中表现出非线性动态,生物能学,抗氧化防御和信号传递的功能障碍.
- 该研究提供了与年龄相关的脂质组变化和性别特定变化的全面地图.
- 研究结果为开发生物标志物和促进健康衰老的干预措施奠定了基础.
更多相关视频
08:56Quantitative Analysis of the Cellular Lipidome of Saccharomyces Cerevisiae Using Liquid Chromatography Coupled with Tandem Mass Spectrometry
Published on: March 8, 2020
7.5K
10:39Author Spotlight: Improved Lipofuscin Models and Quantification of Outer Segment Phagocytosis Capacity in Highly Polarized Human Retinal Pigment Epithelial Cultures
Published on: April 14, 2023
2.7K
相关概念视频
01:35Asymmetric Lipid Bilayer
7.7K
Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
7.7K
01:29Biosynthesis of Lipids
96
Microbial membranes exhibit remarkable diversity in lipid composition, reflecting evolutionary adaptations to various environmental conditions. The three domains of life—Bacteria, Archaea, and Eukarya—synthesize membrane lipids through distinct biosynthetic pathways, leading to fundamental structural differences that impact membrane stability, function, and adaptability.Fatty Acid-Based Lipids in Bacteria and EukaryaBacteria and eukaryotes share a common fatty acid biosynthesis...
96
01:31Lipid-derived Compounds in the Human Body
5.3K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
5.3K
01:26Aging
185
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
185
01:32Membrane Lipids
25.9K
Lipids are an essential component of all biological membranes. The average lipid content in mammalian membranes is 50%, though it can be as low as 20% in the inner mitochondrial membrane or as high as 80% in the myelin sheath present around the nerve cells.
Phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin are the most common phospholipids present in mammalian membranes. At physiological pH, phosphatidylserine is negatively charged, while the other three...
Phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin are the most common phospholipids present in mammalian membranes. At physiological pH, phosphatidylserine is negatively charged, while the other three...
25.9K
01:19The Effect of Aging on Tissues
2.5K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.5K