参与NRF2和AMPK信号在衰老和孕症:一个消化
Eleni Petsouki1, Vasileios Gerakopoulos2, Despoina D Gianniou3
1Department of Pharmaceutical Sciences, Division of Pharmacognosy, University of Vienna, Faculty of Life Sciences, Josef-Holaubek-Platz 2, 1090, Vienna, Austria.
Redox biology
|July 24, 2025
概括
细胞衰老涉及降低平衡和增加压力. 本综述探讨了NRF2和AMPK信号通路如何影响衰老和哈森-吉尔福德进展综合征.
科学领域:
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
- 老年学是一门学科.
背景情况:
- 老龄化是一个自然过程,其特点是生理功能下降和疾病风险增加.
- 细胞平衡在衰老过程中受到损害,导致压力反应,能量和营养代谢的失衡.
- 核因子E2 p45相关因子2 (NRF2) 和AMP激活蛋白激酶 (AMPK) 分别是细胞防御和能量状态的关键调节者.
研究的目的:
- 在衰老的背景下,审查目前对NRF2和AMPK信号的理解.
- 检查NRF2和AMPK在细胞衰老过程中的角色,单独和合作.
- 为了调查这些途径在Hutchinson-Gilford Progeria综合征 (HGPS) 的参与,这是一个过早衰老的疾病.
主要方法:
- 这是一个叙述性综述,综合了现有的NRF2和AMPK信号研究.
- 文献搜索集中在研究NRF2和AMPK在衰老和HGPS中的研究.
- 在细胞应激条件下分析NRF2和AMPK通路之间的相互作用.
主要成果:
- NRF2调节了参与细胞防御抗氧化,蛋白质毒性和异生物应激的基因.
- AMPK充当中央能量传感器,通过调节代谢途径来维持ATP水平.
- 证据表明NRF2和AMPK信号之间存在一种合作相互作用,这超出了压力期间简单的并行激活.
结论:
- NRF2和AMPK信号通路在细胞衰老中起着重要的作用.
- NRF2和AMPK之间的相互作用对于在衰老期间和HGPS中维持细胞平衡至关重要.
- 对这些途径的进一步研究可能会为与年龄有关的疾病和HGPS的治疗策略提供见解.
相关概念视频
mTOR Signaling and Cancer Progression
3.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.9K
PI3K/mTOR/AKT Signaling Pathway
4.0K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
4.0K
NF-κB-dependent Signaling Pathway
7.9K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.9K
The Unfolded Protein Response
5.1K
The ER is the hub of protein synthesis in a cell. It has robust systems to quality control protein folding and also for degradation of terminally misfolded proteins. Under normal conditions, a small proportion of misfolded proteins that cannot be salvaged need to be transported to the cytoplasm by the ER-associated degradation or ERAD pathways. However, if the ERAD cannot handle the misfolded proteins, the cell activates the unfolded protein response or UPR to adjust the protein folding...
5.1K
Aging
185
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
185
Mitochondria
15.0K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
15.0K


