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Updated: Sep 14, 2025

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CHK1-S是一种CHK1的拼接变体,可以抑制慢性髓性白血病

Hu Lei1, Hanzhang Xu1, Yingying Wang1

  • 1Institute for Translational Medicine on Cell Fate and Disease, Shanghai Ninth People's Hospital, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Leukemia research
|July 24, 2025
PubMed
概括

检查点激酶1-S (CHK1-S) 通过反对CHK1活动来抑制慢性髓性白血病 (CML). 在CML患者中减少的CHK1-S突出了其作为瘤抑制剂的作用.

关键词:
一个瑞士克朗.在CHK1-S中使用.慢性骨髓性白血病 慢性骨髓性白血病在TRA2中,TRA2是TRA2.

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RNA Splicing01:32

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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
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