循环瘤DNA用于增强PET-CT,以确定头癌治疗后的临床结果
Sumrit Bola1, Anthony Cutts2, Dimitris Vavoulis3
1Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
European journal of cancer (Oxford, England : 1990)
|July 24, 2025
概括
液体活检 (LB) 在评估头癌治疗响应方面比PET-CT更准确. 这种循环瘤DNA测试可以改善临床决策,补充成像以获得更好的患者结果.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断
- 医疗成像医学成像
背景情况:
- pozitron发射断层扫描-计算机断层扫描 (PET-CT) 和磁共振成像 (MRI) 是评估头癌治疗反应的标准.
- 模两可的成像发现可能导致延迟或不必要的干预,影响患者管理.
- 液体活检 (LB) 提供了一种最少的侵入性方法来检测循环瘤DNA (ctDNA).
研究的目的:
- 为了评估液体活检 (LB) 的有效性,使用ctDNA分析来确定头癌治疗后的治疗反应.
- 将LB的诊断性能与PET-CT和MRI等传统成像方法进行比较.
- 评估LB在帮助接受化疗放射治疗 (CRT) 和手术的患者的临床决策方面的潜在作用.
主要方法:
- 招募了41名接受CRT和/或手术治疗头癌的患者.
- 通过下一代测序收集治疗前和治疗后10-12周的连续血液样本,用于通过下一代测序进行ctDNA分析.
- PET-CT/MRI发现与事后确定的真实疾病状况相关,以及LB结果.
主要成果:
- 与PET-CT相比,液体活检显示出更高的灵敏度 (83%) 和特异性 (95%) (67%的灵敏度,42%的特异性) 在CRT后评估疾病状况时.
- 结合LB和成像方法实现了100%的灵敏度和90%的特异性,显著提高了诊断准确度,而不是仅仅通过成像.
- 综合方法的增强的特异性和平衡的准确性在统计学上是显著的.
结论:
- 液体活检是一种比PET-CT更准确的方法,用于确定头癌化学放射治疗后的真正疾病状况.
- 腰带可以有效地补充治疗后成像,帮助接受CRT和/或手术治疗的患者进行临床决策.
- 整合LB进入治疗后监测有望优化患者管理和结果.
更多相关视频
10:29Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence
Published on: August 14, 2019
10.7K
10:27Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
7.4K
相关概念视频
01:29Positron Emission Tomography
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
01:13Radiological Investigation III: Pulmonary Angiogram and PET Scan
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
01:25Imaging Studies II: Positron Emission Tomography and Scintigraphy
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Fundamental Principles of PET