源自Ganoderma calidophilum的高氧化拉诺斯坦三:通过AMPK/mTOR/SIRT1轴调节和肠-大脑轴交叉通话来实现多目标神经保护

Yi-Fan Guo1, Yu-Zhu Feng1, Jia-Yang Xu1

  • 1Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, Shaanxi, People's Republic of China.

Bioorganic chemistry
|July 24, 2025
PubMed
概括

甘多德玛·卡利多菲勒姆 (Ganoderma calidophilum triterpenoids) 通过降低氧化应激,对降低谷氨酸毒性产生神经保护作用. 加卡利F (6) 调节关键通路和肠道微生物群,为神经退行性疾病的预防提供了潜在的潜力.