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化学抗原受体T细胞在治疗不耐药的DAGLA抗体相关脑炎中

Tobias Hegelmaier¹, Denise Wolleschak², Vaia Pappa³

¹Department of Neurology and Clinical Neurophysiology, Hannover Medical School, Hannover, Germany; Department of Neurology, Otto von Guericke University Magdeburg, Magdeburg, Germany.

Med (New York, N.Y.)

|July 24, 2025

概括

化学抗原受体 (CAR) T细胞疗法为严重的自身免疫性脑炎提供了有前途的治疗方法. 这项案例研究显示,在患有抗抗糖醇脂酶α (DAGLA) 抗体相关脑炎的患者中,该患者的成功结果与其他治疗不相容.

科学领域:

神经免疫学神经免疫学
细胞疗法细胞疗法
自身免疫性疾病自身免疫性疾病

背景情况:

自身免疫性脑是与自身抗体相关的严重中枢神经系统疾病.
这些情况可能会危及生命,并且很难有效治疗.

研究的目的:

描述一种与治疗不耐药的抗甲基甘油脂酶α (DAGLA) 抗体相关的自身免疫脑炎病例.
在这种严重的病例中,评估化学抗原受体 (CAR) T 细胞治疗的疗效.

主要方法:

患者接受了一次抗CD19 CAR T细胞 (KYV-101) 的静脉注射,以治疗B细胞枯竭.
使用标准化神经学尺度 (ICARS,CASE) 评估了临床反应,并测量了抗DAGLA抗体水平.
通过对患者血清,脑脊液和小鼠大脑组织的免疫光检测证实了自身抗体的存在.

主要成果:

一名36岁的男性患有耐火抗DAGLA抗体脑炎,在CAR T细胞治疗后显示出显著的临床改善.
治疗导致抗DAGLA抗体水平降低,大脑脊髓液的奥利古克隆性带的分离.
患者经历了显著改善的肌,震,阴囊和四周.

结论:

抗CD19CAR T细胞疗法对严重的,治疗不耐药的自身免疫脑炎具有显著的治疗潜力.
这种方法为那些对传统疗法没有反应的患者提供了一种新的治疗选择.

关键词:

通过CD19-CAR T细胞治疗.翻译给患者使用.抗达格拉抗体自身抗体.耐火性自身免疫性脑炎

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